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Group of Prof. Dr. Paul Knochel | Department Chemie | Ludwig-Maximilians-Universität




  • OCIV Scripts are now ONLINE.

  • The 2015-2016 Scripts and Exercises for Stereochemistry are now ONLINE.

  • Professor Gary Molander and Professor Paul Knochel have won the 2015 American Publishers PROSE Award for a Multivolume Reference/Science publication, as Editors in Chief of Comprehensive Organic Synthesis. Announced at the Professional and Scholarly Publishing Conference in Washington, DC, the awards are for books and journals that change how we understand the world around us, and benefit our society through the sharing of knowledge.

  • The Paul Karrer gold medal 2015 has been awarded to Paul Knochel.
    The Karrer medal is an international award that recognizes great achivements in science centered on organic chemistry. This awards shows the central place of organic chemistry thriving in the areas of medical science, materials eingineering, and molecular synthesis.

  • The Herbert C. Brown Award for Creative Research in Synthetic Methods 2014 has been awarded to Paul Knochel.
    The H.C. Brown Award is awarded in order to recognize and encourage outstanding and creative contributions to research in synthetic methods.
  • The Gold Nagoya Medal of Organic Chemistry 2012 has been awarded to Paul Knochel.
    The Gold Medal is awarded every year to an organic chemist who has made significant original contributions to the field in its broadest sense.

Recent Publications





  • Castello-Mico, A.; Herbert, S. A.; Leon, T.; Bein, T.; Knochel, P. Functionalizations of Mixtures of Regioisomeric Aryllithium Compounds by Selective Trapping with Dichlorozirconocene. Angew. Chem. Int. Ed.  2016, 55, 401-404.

  • Moegling, J.; Benischke, A. D.; Hammann, J. M.; Veprek, N. A.; Zoller, F.; Rendenbach, B.; Hoffmann, A.; Sievers, H.; Schuster, M.; Knochel, P.; Herres-Pawlis S. Bis(pyrazolyl)methane Copper Complexes as Robust and Efficient Catalysts for Sonogashira Couplings. Eur. J. Org. Chem. 2015, 7475-7483.

  • Becker, M. R.,  Knochel, P. Practical Continuous-Flow Trapping Metalations of Functionalized Arenes and Heteroarenes Using TMPLi in the Presence of Mg, Zn, Cu, or La Halides. Angew. Chem. Int. Ed. 201554, DOI: 10.1002/anie.201502393

  • Corral-Bautista, F.; Klier, L.; Knochel, P.; Mayr, H. From Carbanions to Organometallic Compounds: Quantification of Metal Ion Effects on Nucleophilic Reactivities. Angew. Chem. Int. Ed. 201554, DOI: 10.1002/anie.201501385


  • Kuzmina, O. M.; Steib, A. K.; Fernandez, S.; Boudot, W.; Markiewicz, J. T.; Knochel, P. Practical Iron- and Cobalt-Catalyzed Cross-Coupling Reactions between N-Heterocyclic Halides and Aryl or Heteroaryl Magnesium Reagents. Chem. Eur. J. 2015, 21, 8242-8249.

  • Klatt, T.; Werner, V.; Maximova, M. G.; Didier, D.; Apeloig, Y.; Knochel, P. Preparation and Regioselective Magnesiation or Lithiation of Bis(trimethylsilyl)methyl-Substituted Heteroaryls for the Generation of Highly Functionalized Heterocycles. Chem. Eur. J. 2015, 21, 7830-7834.

  • Hammann, J. M.; Haas, D.; Knochel, P. Cobalt-Catalyzed Negishi Cross-Coupling Reactions of (Hetero)Arylzinc Reagents with Primary and Secondary Alkyl Bromides and Iodides. Angew. Chem. Int. Ed. 201554, 4478-4481.

  • Moriya, K.; Didier, D.; Simon, M.; Hammann, J. M.; Berionni, G.; Karaghiosoff, K.; Zipse, H.; Mayr, H.; Knochel, P. Stereoselective Synthesis and Reactions of Secondary Alkyllithium Reagents Functionalized at the 3-Position. Angew. Chem. Int. Ed. 201554, 2754-2757.

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